Histone lactylation: a new epigenetic axis for host-parasite signalling in malaria?

Merrick, Catherine J

Merrick, Catherine J.

Afiliación

Merrick CJ; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK. Electronic address: cjm48@cam.ac.uk.

Trends Parasitol ; 39(1): 12-16, 2023 01.

Article en En | MEDLINE | ID: mdl-36357308

RESUMEN

Epigenetic modifications play important roles in the biology of malaria parasites. The new epigenetic mark histone lactylation, discovered only recently in humans, is also present in malaria parasites. It may have important functions as a key player in the epigenetic repertoire of Plasmodium.

Asunto(s)

Malaria; Parásitos; Animales; Humanos; Histonas/genética; Histonas/metabolismo; Parásitos/metabolismo; Plasmodium falciparum/metabolismo; Malaria/parasitología; Epigénesis Genética

Palabras clave

Plasmodium; epigenetics; hyperlactataemia; lactate; lactylation; malaria

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_malaria / 3_neglected_diseases / 3_zoonosis Asunto principal: Parásitos / Malaria Límite: Animals / Humans Idioma: En Revista: Trends Parasitol Asunto de la revista: PARASITOLOGIA Año: 2023 Tipo del documento: Article

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