Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa.

Tian, Sixin; Durek, Thomas; Wang, Conan K; Zdenek, Christina N; Fry, Bryan G; Craik, David J; de Veer, Simon J

Tian, Sixin; Durek, Thomas; Wang, Conan K; Zdenek, Christina N; Fry, Bryan G; Craik, David J; de Veer, Simon J.

Afiliación

Tian S; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
Durek T; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
Wang CK; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
Zdenek CN; Venom Evolution Lab, School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
Fry BG; Venom Evolution Lab, School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
Craik DJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
de Veer SJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.

J Med Chem ; 65(23): 15698-15709, 2022 12 08.

Article en En | MEDLINE | ID: mdl-36383928

Asunto(s)

Factor XIIa; Humanos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor XIIa Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Australia

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