Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice.
Oncoimmunology
; 11(1): 2146855, 2022.
Article
en En
| MEDLINE
| ID: mdl-36387057
ABSTRACT
Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espermidina
/
Inmunoterapia
Límite:
Animals
Idioma:
En
Revista:
Oncoimmunology
Año:
2022
Tipo del documento:
Article
País de afiliación:
Suecia