Defucosylated Mouse-Dog Chimeric Anti-Human Epidermal Growth Factor Receptor 2 Monoclonal Antibody (H77Bf) Exerts Antitumor Activities in Mouse Xenograft Models of Canine Osteosarcoma.

Nanamiya, Ren; Ohishi, Tomokazu; Suzuki, Hiroyuki; Mizuno, Takuya; Yoshikawa, Takeo; Asano, Teizo; Tanaka, Tomohiro; Kaneko, Mika K; Kato, Yukinari

Nanamiya, Ren; Ohishi, Tomokazu; Suzuki, Hiroyuki; Mizuno, Takuya; Yoshikawa, Takeo; Asano, Teizo; Tanaka, Tomohiro; Kaneko, Mika K; Kato, Yukinari.

Afiliación

Nanamiya R; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Ohishi T; Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Shizuoka, Japan.
Suzuki H; Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Mizuno T; Laboratory of Molecular Diagnostics and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
Yoshikawa T; Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Asano T; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Tanaka T; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Kaneko MK; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Kato Y; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Monoclon Antib Immunodiagn Immunother ; 42(1): 27-33, 2023 Feb.

Article en En | MEDLINE | ID: mdl-36399552

Asunto(s)

Antineoplásicos; Osteosarcoma; Humanos; Ratones; Perros; Animales; Anticuerpos Monoclonales; Xenoinjertos; Receptor ErbB-2; Antineoplásicos/farmacología; Osteosarcoma/tratamiento farmacológico; Ensayos Antitumor por Modelo de Xenoinjerto; Línea Celular Tumoral; Citotoxicidad Celular Dependiente de Anticuerpos

Palabras clave

ADCC; CDC; HER2; antitumor activity; canine osteosarcoma; mouse-dog chimeric antibody

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteosarcoma / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Monoclon Antib Immunodiagn Immunother Año: 2023 Tipo del documento: Article País de afiliación: Japón

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