Your browser doesn't support javascript.
loading
Assessment of Functional and Nutritional Status and Skeletal Muscle Mass for the Prognosis of Critically Ill Solid Cancer Patients.
Vigneron, Clara; Laousy, Othmane; Chassagnon, Guillaume; Vakalopoulou, Maria; Charpentier, Julien; Alexandre, Jérôme; Jamme, Matthieu; Pène, Frédéric.
Afiliación
  • Vigneron C; Service de Médecine Intensive-Réanimation, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Centre-Université Paris Cité, 75014 Paris, France.
  • Laousy O; Université Paris Cité, 75014 Paris, France.
  • Chassagnon G; Service de Radiologie, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Centre-Université Paris Cité, 75014 Paris, France.
  • Vakalopoulou M; Ecole CentraleSupelec, Mathématiques et Informatique pour la Complexité et les Systèmes, Université Paris-Saclay, 91190 Gif-sur-Yvette, France.
  • Charpentier J; Université Paris Cité, 75014 Paris, France.
  • Alexandre J; Service de Radiologie, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Centre-Université Paris Cité, 75014 Paris, France.
  • Jamme M; Ecole CentraleSupelec, Mathématiques et Informatique pour la Complexité et les Systèmes, Université Paris-Saclay, 91190 Gif-sur-Yvette, France.
  • Pène F; Service de Médecine Intensive-Réanimation, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Centre-Université Paris Cité, 75014 Paris, France.
Cancers (Basel) ; 14(23)2022 Nov 29.
Article en En | MEDLINE | ID: mdl-36497352
Simple and accessible prognostic factors are paramount for solid cancer patients experiencing life-threatening complications. The aim of this study is to appraise the impact of functional and nutritional status and skeletal muscle mass in this population. We conducted a retrospective (2007−2020) single-center study by enrolling adult patients with solid cancers requiring unplanned ICU admission. Performance status, body weight, and albumin level were collected at ICU admission and over six months. Skeletal muscle mass was assessed at ICU admission by measuring muscle areas normalized by height (SMI). Four-hundred and sixty-two patients were analyzed, mainly with gastro-intestinal (34.8%) and lung (29.9%) neoplasms. Moreover, 92.8% of men and 67.3% of women were deemed cachectic. In the multivariate analysis, performance status at ICU admission (CSH 1.74 [1.27−2.39], p < 0.001) and the six month increase in albumin level (CSH 0.38 [0.16−0.87], p = 0.02) were independent predictors of ICU mortality. In the subgroup of mechanically ventilated patients, the psoas SMI was independently associated with ICU mortality (CSH 0.82 [0.67−0.98], p = 0.04). Among the 368 ICU-survivors, the performance status at ICU admission (CSH 1.34 [1.14−1.59], p < 0.001) and the six-month weight loss (CSH 1.33 [1.17−2.99], p = 0.01) were associated with a one-year mortality rate. Most cancer patients displayed cachexia at ICU admission. Time courses of nutritional parameters may aid the prediction of short- and long-term outcomes.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Cancers (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Cancers (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Francia
...