Dysregulation and implications of lncRNAs and miRNAs in oral tongue squamous cell carcinoma: In reply with emphasis on the role of ceRNAs.
Oral Oncol
; 136: 106277, 2023 01.
Article
en En
| MEDLINE
| ID: mdl-36508884
ABSTRACT
Increasing evidence indicates that long noncoding RNAs (lncRNAs) as competing endogenous RNAs (ceRNAs) competitively sequestering microRNAs (miRNAs) participate in biological processes of oral tongue squamous cell carcinoma (TSCC). In this Letter, the ceRNA regulatory networks consisting of lncRNA/miRNA/mRNA axes in TSCC were summarized. Dysregulated profiles containing 33 lncRNAs and 31 miRNAs were identified by cancer-associated phenotypes verification. Almost all the lncRNAs could exert the oncogenic roles to sponge miRNAs and regulate targeting mRNA expression, thereby modulating cell proliferation, cell cycle, apoptosis, invasion, migration, metastasis, epithelial-mesenchymal transition, as well as chemoresistance. Significantly, the implications of functional ceRNAs deactivated in tumor cells contribute to the exploitation of novel diagnostic and therapeutic strategies for TSCC.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Lengua
/
MicroARNs
/
ARN Largo no Codificante
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Carcinoma de Células Escamosas de Cabeza y Cuello
Límite:
Humans
Idioma:
En
Revista:
Oral Oncol
Asunto de la revista:
NEOPLASIAS
Año:
2023
Tipo del documento:
Article