AKT1 phosphorylates RBM17 to promote Sox2 transcription by modulating alternative splicing of FOXM1 to enhance cancer stem cell properties in colorectal cancer cells.

Fu, Yan; Bai, Chen; Wang, Shengsheng; Chen, Denggang; Zhang, Peng; Wei, Hailang; Rong, Fan; Zhang, Chao; Chen, Shaojuan; Wang, Zhenjun

Fu, Yan; Bai, Chen; Wang, Shengsheng; Chen, Denggang; Zhang, Peng; Wei, Hailang; Rong, Fan; Zhang, Chao; Chen, Shaojuan; Wang, Zhenjun.

Afiliación

Fu Y; Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.
Bai C; Department of General Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Wang S; Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Chen D; Center for Evidence Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Zhang P; Department of General Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Wei H; Department of General Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Rong F; Department of General Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Zhang C; Department of General Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Chen S; Department of General Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Wang Z; Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, China.

FASEB J ; 37(1): e22707, 2023 01.

Article en En | MEDLINE | ID: mdl-36520054

Asunto(s)

Neoplasias Colorrectales; Humanos; Empalme Alternativo; Línea Celular Tumoral; Proliferación Celular; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/metabolismo; Proteína Forkhead Box M1/genética; Proteína Forkhead Box M1/metabolismo; Regulación Neoplásica de la Expresión Génica; Células Madre Neoplásicas/metabolismo; Proteínas Proto-Oncogénicas c-akt/genética; Proteínas Proto-Oncogénicas c-akt/metabolismo; Factores de Empalme de ARN/metabolismo; Factores de Transcripción SOXB1/genética; Factores de Transcripción SOXB1/metabolismo

Palabras clave

RBM17; alternative splicing; cancer stem cells; colorectal cancer

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_colon_rectum_cancers Asunto principal: Neoplasias Colorrectales Límite: Humans Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2023 Tipo del documento: Article

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