HIV and race are independently associated with endothelial dysfunction.
AIDS
; 37(2): 271-277, 2023 02 01.
Article
en En
| MEDLINE
| ID: mdl-36541639
ABSTRACT
OBJECTIVE:
Evaluating the vascular function in HIV-infected compared with HIV uninfected with assessment of body composition, inflammation, and gut integrity markers.DESIGN:
A noninvasive test that measures the endothelial function.METHODS:
We included participants at least 18âyears old, with peripheral arterial tonometry testing (EndoPAT2000) between 2014 and 2022. Persons with HIV (PWH) had documented infection, a stable ART regimen, and a viral load less than 400âcopies/ml. We measured the vessel's function with the reactive hyperemia index (RHI) (normal >1.67) and Augmentation Index. Lower Augmentation Index reflect better arterial elasticity. We assessed markers of systemic inflammation, immune activation, and gut integrity. We used linear mixed models to estimate endothelial dysfunction with a significant P value less than 0.05.RESULTS:
Overall, 511 participants (296 HIV-infected; 215 HIV-uninfected controls) were included. Estimated RHI among PWH was 13% lower (Pâ=â0.01) compared with persons without HIV. In nonwhite race, the estimated RHI was 9% lower (Pâ=â0.001) than white race. For every 1% increase in BMI, we would expect RHI to increase 0.17% (Pâ=â0.01). At the time of EndoPAT, the estimated RHI was 8% lower (Pâ=â0.04) among protease inhibitor users compared with PWH who were not taking protease inhibitors. The estimated odds of abnormal RHI ≤1.67) is 1.56 times greater [95% confidence interval (CI) 1.05-2.31] in nonwhite race compared with white race, independent of HIV status [ORâ=â1.4 (95% CI 0.94-2.13)]. There was not enough evidence to suggest that inflammation, gut, or monocyte markers, current or nadir CD4+ cell count, or duration of HIV were associated with endothelial dysfunction.CONCLUSION:
HIV, nonwhite race, and protease inhibitor use are independently associated with endothelial dysfunction.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_enfermedades_transmissibles
Asunto principal:
Infecciones por VIH
/
Hiperemia
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
Límite:
Adolescent
/
Humans
Idioma:
En
Revista:
AIDS
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
2023
Tipo del documento:
Article