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Emerging immunomodulatory strategies for cell therapeutics.
Chua, Corrine Ying Xuan; Jiang, Allen Yujie; Eufrásio-da-Silva, Tatiane; Dolatshahi-Pirouz, Alireza; Langer, Robert; Orive, Gorka; Grattoni, Alessandro.
Afiliación
  • Chua CYX; Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA.
  • Jiang AY; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Eufrásio-da-Silva T; Department of Health Technology, Technical University of Denmark (DTU), 2800 Kgs. Lyngby, Denmark.
  • Dolatshahi-Pirouz A; Department of Health Technology, Technical University of Denmark (DTU), 2800 Kgs. Lyngby, Denmark.
  • Langer R; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Orive G; NanoBioCel Research Group, School of Pharmacy, University of the Basque Country (UPV/EHU), 01006 Vitoria-Gasteiz, Spain; Bioaraba, NanoBioCel Research Group, 01009 Vitoria-Gasteiz, Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Institute of
  • Grattoni A; Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Radiation Oncology, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Surgery, Houston Methodist Research Institute, Houston, TX 77030, USA. Electronic address: agrattoni
Trends Biotechnol ; 41(3): 358-373, 2023 03.
Article en En | MEDLINE | ID: mdl-36549959
Cellular therapies are poised to transform the field of medicine by restoring dysfunctional tissues and treating various diseases in a dynamic manner not achievable by conventional pharmaceutics. Spanning various therapeutic areas inclusive of cancer, regenerative medicine, and immune disorders, cellular therapies comprise stem or non-stem cells derived from various sources. Despite numerous clinical approvals or trials underway, the host immune response presents a critical impediment to the widespread adoption and success of cellular therapies. Here, we review current research and clinical advances in immunomodulatory strategies to mitigate immune rejection or promote immune tolerance to cellular therapies. We discuss the potential of these immunomodulatory interventions to accelerate translation or maximize the prospects of improving therapeutic outcomes of cellular therapies for clinical success.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tratamiento Basado en Trasplante de Células y Tejidos / Tolerancia Inmunológica Idioma: En Revista: Trends Biotechnol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tratamiento Basado en Trasplante de Células y Tejidos / Tolerancia Inmunológica Idioma: En Revista: Trends Biotechnol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos