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Zingerone Attenuates Carfilzomib-Induced Cardiotoxicity in Rats through Oxidative Stress and Inflammatory Cytokine Network.
Alam, Mohammad Firoz; Hijri, Sami I; Alshahrani, Saeed; Alqahtani, Saad S; Jali, Abdulmajeed M; Ahmed, Rayan A; Adawi, Mansour M; Algassmi, Sameeh M; Shaheen, Emad Sayed; Moni, Sivakumar S; Anwer, Tarique.
Afiliación
  • Alam MF; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
  • Hijri SI; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
  • Alshahrani S; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
  • Alqahtani SS; Department of Pharmacy Practice, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
  • Jali AM; Pharmacy Practice Research Unit, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
  • Ahmed RA; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
  • Adawi MM; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
  • Algassmi SM; Department of Histopathology, King Fahad Hospital, Jazan 45142, Saudi Arabia.
  • Shaheen ES; Department of Histopathology, King Fahad Hospital, Jazan 45142, Saudi Arabia.
  • Moni SS; Department of Animal House, Medical Research Centre, Jazan University, Jazan 45142, Saudi Arabia.
  • Anwer T; Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
Int J Mol Sci ; 23(24)2022 Dec 09.
Article en En | MEDLINE | ID: mdl-36555257
Carfilzomib (CFZ) is an anticancer medication acting as a selective proteasome inhibitor. However, it can cause cardiovascular problems, increasing mortality and morbidity. This study aimed to investigate whether zingerone (ZRN) could help reduce carfilzomib-induced cardiotoxicity in Wistar albino rats. Rats were divided into five groups of six animals each. The first group received normal saline as a control (NC); the second group received multiple doses (six) of CFZ (4 mg/kg) intraperitoneally (IP); the third and fourth groups received zingerone (50 mg/kg and 100 mg/kg oral) along with six doses of CFZ for 16 days; and the fifth group received only 100 mg/kg zingerone orally. Hematological, biochemical, oxidative stress, and histopathological studies confirmed the findings of CFZ-induced cardiotoxicity. We found that ZRN significantly attenuated the effects of CFZ on oxidative stress by enhancing the antioxidant properties of glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD). Additionally, ZRN reduces inflammatory cytokines and apoptotic markers, such as IL-1ß, IL-6, TNFα, and caspase-3. Overall, zingerone prevents carfilzomib-induced cardiotoxicity in rats, as evidenced by histopathological studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 1_doencas_nao_transmissiveis / 6_cardiovascular_diseases Asunto principal: Citocinas / Cardiotoxicidad Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Arabia Saudita

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 1_doencas_nao_transmissiveis / 6_cardiovascular_diseases Asunto principal: Citocinas / Cardiotoxicidad Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Arabia Saudita
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