An autophagy-inducing stapled peptide promotes c-MET degradation and overrides adaptive resistance to sorafenib in c-MET<sup>+</sup> hepatocellular carcinoma.

Gao, Shan; Li, Na; Zhang, Xiaozhe; Chen, Jingyi; Ko, Ben C B; Zhao, Yanxiang

An autophagy-inducing stapled peptide promotes c-MET degradation and overrides adaptive resistance to sorafenib in c-MET⁺ hepatocellular carcinoma.

Gao, Shan; Li, Na; Zhang, Xiaozhe; Chen, Jingyi; Ko, Ben C B; Zhao, Yanxiang.

Afiliación

Gao S; Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, 999077, PR China.
Li N; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, 518057, PR China.
Zhang X; Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, 999077, PR China.
Chen J; Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, 999077, PR China.
Ko BCB; Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, 999077, PR China.
Zhao Y; Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, 999077, PR China.

Biochem Biophys Rep ; 33: 101412, 2023 Mar.

Article en En | MEDLINE | ID: mdl-36578529

Palabras clave

Autophagy; EGFR; Endolysosomal degradation; HCC; c-MET

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biochem Biophys Rep Año: 2023 Tipo del documento: Article