Identification of the inhibitory mechanism of ecumicin and rufomycin 4-7 on the proteolytic activity of Mycobacterium tuberculosis ClpC1/ClpP1/ClpP2 complex.

Hong, Jeongpyo; Duc, Nguyen Minh; Jeong, Byeong-Chul; Cho, Sanghyun; Shetye, Gauri; Cao, Jin; Lee, Hyun; Jeong, Cherlhyun; Lee, Hanki; Suh, Joo-Won

Hong, Jeongpyo; Duc, Nguyen Minh; Jeong, Byeong-Chul; Cho, Sanghyun; Shetye, Gauri; Cao, Jin; Lee, Hyun; Jeong, Cherlhyun; Lee, Hanki; Suh, Joo-Won.

Afiliación

Hong J; Interdisciplinary Program of Biomodulation, Graduate School, Myongji University, Yongin, Gyeonggi-do, 17058, Republic of Korea.
Duc NM; Interdisciplinary Program of Biomodulation, Graduate School, Myongji University, Yongin, Gyeonggi-do, 17058, Republic of Korea.
Jeong BC; Division of Biosciences and Bioinformatics, College of Natural Science, Myongji University, Yongin, Gyeonggi-do, 17058, Republic of Korea.
Cho S; Institute for Tuberculosis Research, Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, United States.
Shetye G; Institute for Tuberculosis Research, Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, United States.
Cao J; Institute for Tuberculosis Research, Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, United States.
Lee H; Biophysics Core at Resource Center, University of Illinois at Chicago, Chicago, IL, 60612, United States.
Jeong C; Chemical & Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea; KHU-KIST Department of Converging Science and Technology, Kyunghee University, Seoul, 02447, Republic of Korea. Electronic address: che.jeong@kist.re.kr.
Lee H; Interdisciplinary Program of Biomodulation, Graduate School, Myongji University, Yongin, Gyeonggi-do, 17058, Republic of Korea. Electronic address: hklee95@mju.ac.kr.
Suh JW; MJ Bioefficacy Research Center, Myongji University, Yongin, Gyeonggi-do, 17058, Republic of Korea. Electronic address: jwsuh@mju.ac.kr.

Tuberculosis (Edinb) ; 138: 102298, 2023 01.

Article en En | MEDLINE | ID: mdl-36580851

Asunto(s)

Mycobacterium tuberculosis; Mycobacterium tuberculosis/genética; Proteínas Bacterianas/metabolismo; Adenosina Trifosfatasas/metabolismo; Adenosina Trifosfatasas/farmacología

Palabras clave

Abnormal ClpC1; ClpC1; Ecumicin; Intermolecular dynamics of ClpC1; Rufomycin 4-7

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND Problema de salud: 2_enfermedades_transmissibles / 3_neglected_diseases / 3_tuberculosis Asunto principal: Mycobacterium tuberculosis Tipo de estudio: Diagnostic_studies Idioma: En Revista: Tuberculosis (Edinb) Año: 2023 Tipo del documento: Article

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