TLR7 agonism accelerates disease in a mouse model of primary Sjögren's syndrome and drives expansion of T-bet<sup>+</sup> B cells.

Punnanitinont, Achamaporn; Kasperek, Eileen M; Kiripolsky, Jeremy; Zhu, Chengsong; Miecznikowski, Jeffrey C; Kramer, Jill M

TLR7 agonism accelerates disease in a mouse model of primary Sjögren's syndrome and drives expansion of T-bet⁺ B cells.

Punnanitinont, Achamaporn; Kasperek, Eileen M; Kiripolsky, Jeremy; Zhu, Chengsong; Miecznikowski, Jeffrey C; Kramer, Jill M.

Afiliación

Punnanitinont A; Department of Oral Biology, School of Dental Medicine, The University at Buffalo, State University of New York, Buffalo, NY, United States.
Kasperek EM; Department of Oral Biology, School of Dental Medicine, The University at Buffalo, State University of New York, Buffalo, NY, United States.
Kiripolsky J; Department of Oral Biology, School of Dental Medicine, The University at Buffalo, State University of New York, Buffalo, NY, United States.
Zhu C; Department of Immunology, Microarray & Immune Phenotyping Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Miecznikowski JC; Department of Biostatistics, School of Public Health and Health Professions, The University at Buffalo, State University of New York, Buffalo, NY, United States.
Kramer JM; Department of Oral Biology, School of Dental Medicine, The University at Buffalo, State University of New York, Buffalo, NY, United States.

Front Immunol ; 13: 1034336, 2022.

Article en En | MEDLINE | ID: mdl-36591307

Asunto(s)

Linfocitos B; Factor 88 de Diferenciación Mieloide; Síndrome de Sjögren; Receptor Toll-Like 7; Animales; Femenino; Ratones; Adyuvantes Inmunológicos/farmacología; Ratones Endogámicos C57BL; Ratones Endogámicos NOD; Factor 88 de Diferenciación Mieloide/genética; Factor 88 de Diferenciación Mieloide/inmunología; Síndrome de Sjögren/genética; Síndrome de Sjögren/inmunología; Receptor Toll-Like 7/agonistas; Receptor Toll-Like 7/genética; Receptor Toll-Like 7/inmunología; Linfocitos B/efectos de los fármacos; Linfocitos B/inmunología; Imiquimod/farmacología

Palabras clave

ABC; NOD.B10; age-associated B cells; autoantibodies; autoimmunity; sialadenitis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Síndrome de Sjögren / Receptor Toll-Like 7 / Factor 88 de Diferenciación Mieloide Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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