Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions.
Cold Spring Harb Perspect Med
; 13(2)2023 02 01.
Article
en En
| MEDLINE
| ID: mdl-36617642
ABSTRACT
Retinal degeneration is an increasing global burden without cure for the majority of patients. Once retinal cells have degenerated, vision is permanently lost. Different strategies have been developed in recent years to prevent retinal degeneration or to restore sight (e.g., gene therapy, cell therapy, and electronic implants). Herein, we present current treatment strategies with a focus on cell therapy for photoreceptor replacement using human pluripotent stem cells. We will describe the state of the art and discuss obstacles and limitations observed in preclinical animal models as well as future directions to improve graft integration and functionality.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Degeneración Retiniana
/
Células Madre Pluripotentes
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cold Spring Harb Perspect Med
Año:
2023
Tipo del documento:
Article
País de afiliación:
Francia