Your browser doesn't support javascript.
loading
Emergence and spread of MT28 ptxP3 allele macrolide-resistant Bordetella pertussis from 2021 to 2022 in China.
Fu, Pan; Zhou, Jinlan; Meng, Jianhua; Liu, Zhiwei; Nijiati, Yaxier; He, Leiyan; Li, Chunling; Chen, Saige; Wang, Aimin; Yan, Gangfeng; Lu, Guoping; Zhou, Lijun; Zhai, Xiaowen; Wang, Chuanqing.
Afiliación
  • Fu P; Department of Clinical Microbiology Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China; Nosocomial Infection Control Department, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Zhou J; Pediatric intensive care unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Meng J; Department of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Liu Z; Department of Clinical Laboratory, Taian Maternity and Child Health Hospital, Taian, Shandong Province, China.
  • Nijiati Y; Orthopedics Department, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • He L; Department of Clinical Microbiology Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Li C; Department of Clinical Microbiology Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Chen S; Department of Clinical Microbiology Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Wang A; Department of Clinical Microbiology Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Yan G; Pediatric intensive care unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Lu G; Pediatric intensive care unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
  • Zhou L; Outpatient and Emergency Management Office, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. Electronic address: 13816881217@163.com.
  • Zhai X; Department of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. Electronic address: xwxhai@fudan.edu.cn.
  • Wang C; Department of Clinical Microbiology Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China; Nosocomial Infection Control Department, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. Electronic address: chu
Int J Infect Dis ; 128: 205-211, 2023 Mar.
Article en En | MEDLINE | ID: mdl-36632892
ABSTRACT

OBJECTIVES:

To reveal the clinical and molecular characteristics of Bordetella pertussis (BP) prevalent in Shanghai, China.

METHODS:

A total of 9430 children with suspected pertussis from 2021 to 2022 were included, and nasopharyngeal swab samples were collected for polymerase chain reaction detection, culture, antimicrobial susceptibility testing, and 23S rRNA gene A2047G detection. BP strains were typed using multilocus variable-number tandem-repeat analysis and virulence genotyping.

RESULTS:

Of 9430 cases, 5.1% and 1.6% were confirmed by polymerase chain reaction and culture, respectively. Infants (aged <1 year) accounted for 24.7% and presented much more severe symptoms than noninfants. Pertussis was most frequently detected in infants aged 0-6 months (11.3∼14.0%) and children aged >6-10 years (10.8∼21.7%). Macrolide-resistant BP (MRBP) accounted for 89.3%, and all carried the A2047G mutation. There were six multilocus variable-number tandem-repeat analysis types (MTs), including MT28 (62.0%), MT195 (20%), MT27 (10.0%), MT104 (4.7%), MT55 (2.7%), and MT32 (0.7%). BP strains with pertussis toxin (ptx)P3/(pertactin) prn2/ptxC2/ptxA1/(fimbrial proteins) fim2-1/fim3-1, including MT27, MT28, and MT32, accounted for 72.7%, among which MT27 and MT32 were macrolide-sensitive BP, whereas most (94.6∼100%) of MT28 were MRBP. Strains harboring ptxP1/prn1/ptxC1/ptxA1/fim2-1/fim3-1, including MT55, MT104, and MT195, belonged to macrolide-sensitive BP.

CONCLUSION:

The emergence and spread of MT28 ptxP3-MRBP was first reported in China, highlighting the importance of continuous surveillance of ptxP3-MRBP to prevent its potential circulation.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bordetella pertussis / Tos Ferina / Farmacorresistencia Bacteriana Límite: Child / Humans / Infant País/Región como asunto: Asia Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bordetella pertussis / Tos Ferina / Farmacorresistencia Bacteriana Límite: Child / Humans / Infant País/Región como asunto: Asia Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2023 Tipo del documento: Article País de afiliación: China