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Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor.
De Pascale, Martina; Bissegger, Lukas; Tarantelli, Chiara; Beaufils, Florent; Prescimone, Alessandro; Mohamed Seid Hedad, Hayget; Kayali, Omar; Orbegozo, Clara; Raguz, Luka; Schaefer, Thorsten; Hebeisen, Paul; Bertoni, Francesco; Wymann, Matthias P; Borsari, Chiara.
Afiliación
  • De Pascale M; University of Basel, Department of Biomedicine, Mattenstrasse 28, 4058, Basel, Switzerland.
  • Bissegger L; University of Basel, Department of Biomedicine, Mattenstrasse 28, 4058, Basel, Switzerland.
  • Tarantelli C; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Via Francesco Chiesa 5, 6500, Bellinzona, Switzerland.
  • Beaufils F; University of Basel, Department of Biomedicine, Mattenstrasse 28, 4058, Basel, Switzerland.
  • Prescimone A; University of Basel, Department of Chemistry, Mattenstrasse 24a, 4058, Basel, Switzerland.
  • Mohamed Seid Hedad H; University of Basel, Department of Biomedicine, Mattenstrasse 28, 4058, Basel, Switzerland.
  • Kayali O; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Via Francesco Chiesa 5, 6500, Bellinzona, Switzerland.
  • Orbegozo C; University of Basel, Department of Biomedicine, Mattenstrasse 28, 4058, Basel, Switzerland.
  • Raguz L; University of Basel, Department of Biomedicine, Mattenstrasse 28, 4058, Basel, Switzerland.
  • Schaefer T; University of Basel, Department of Biomedicine, Mattenstrasse 28, 4058, Basel, Switzerland.
  • Hebeisen P; University of Basel, Department of Biomedicine, Mattenstrasse 28, 4058, Basel, Switzerland.
  • Bertoni F; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Via Francesco Chiesa 5, 6500, Bellinzona, Switzerland; Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
  • Wymann MP; University of Basel, Department of Biomedicine, Mattenstrasse 28, 4058, Basel, Switzerland. Electronic address: matthias.wymann@unibas.ch.
  • Borsari C; University of Basel, Department of Biomedicine, Mattenstrasse 28, 4058, Basel, Switzerland. Electronic address: chiara.borsari@unibas.ch.
Eur J Med Chem ; 248: 115038, 2023 Feb 15.
Article en En | MEDLINE | ID: mdl-36634458
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serina-Treonina Quinasas TOR / Neoplasias Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article País de afiliación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serina-Treonina Quinasas TOR / Neoplasias Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article País de afiliación: Suiza