Protective role of naftidrofuryl against methotrexate-induced testicular damage via the amelioration of the p53/miRNA-29a/CDC42 apoptotic pathway, inflammation, and oxidative stress.

Waly, Ola Mahmoud; El-Mahdy, Nageh Ahmed; El-Shitany, Nagla Abd El-Aziz; Mohammedsaleh, Zuhair M; El-Kadem, Aya Hassan

Waly, Ola Mahmoud; El-Mahdy, Nageh Ahmed; El-Shitany, Nagla Abd El-Aziz; Mohammedsaleh, Zuhair M; El-Kadem, Aya Hassan.

Afiliación

Waly OM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt. Electronic address: ola149959@pharm.tanta.edu.eg.
El-Mahdy NA; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
El-Shitany NAE; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Mohammedsaleh ZM; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.
El-Kadem AH; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.

Environ Toxicol Pharmacol ; 98: 104067, 2023 Mar.

Article en En | MEDLINE | ID: mdl-36649853

Asunto(s)

MicroARNs; Nafronil; Ratas; Masculino; Animales; Metotrexato/farmacología; Antioxidantes/farmacología; Nafronil/farmacología; Proteína p53 Supresora de Tumor; Estrés Oxidativo; Inflamación; Apoptosis

Palabras clave

Apoptosis; CDC42; Methotrexate; MiRNA-29a; NF-κB; Naftidrofuryl

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_testicular_cancer Asunto principal: MicroARNs / Nafronil Límite: Animals Idioma: En Revista: Environ Toxicol Pharmacol Año: 2023 Tipo del documento: Article

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