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The 2022 RSV surge was driven by multiple viral lineages.
Adams, Gordon; Moreno, Gage K; Petros, Brittany A; Uddin, Rockib; Levine, Zoe; Kotzen, Ben; Messer, Katelyn; Dobbins, Sabrina T; DeRuff, Katherine C; Loreth, Christine; Brock-Fisher, Taylor; Schaffner, Stephen F; Chaluvadi, Sushma; Kanjilal, Sanjat; Luban, Jeremy; Ozonoff, Al; Park, Daniel; Turbett, Sarah; Siddle, Katherine J; MacInnis, Bronwyn L; Sabeti, Pardis; Lemieux, Jacob.
Afiliación
  • Adams G; Massachusetts General Hospital, Boston, MA, 02142.
  • Moreno GK; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Petros BA; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Uddin R; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Levine Z; Division of Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Kotzen B; Harvard/Massachusetts Institute of Technology, MD-PhD Program, Boston, MA, USA.
  • Messer K; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
  • Dobbins ST; Massachusetts General Hospital, Boston, MA, 02142.
  • DeRuff KC; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Loreth C; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Brock-Fisher T; Harvard/Massachusetts Institute of Technology, MD-PhD Program, Boston, MA, USA.
  • Schaffner SF; Harvard Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA.
  • Chaluvadi S; Massachusetts General Hospital, Boston, MA, 02142.
  • Kanjilal S; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Luban J; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Ozonoff A; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Park D; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Turbett S; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Siddle KJ; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • MacInnis BL; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Sabeti P; Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
  • Lemieux J; Brigham and Women's Hospital, Boston, MA, 02115.
medRxiv ; 2023 Jan 05.
Article en En | MEDLINE | ID: mdl-36656774
ABSTRACT
The US experienced an early and severe respiratory syncytial virus (RSV) surge in autumn 2022. Despite the pressure this has put on hospitals and care centers, the factors promoting the surge in cases are unknown. To investigate whether viral characteristics contributed to the extent or severity of the surge, we sequenced 105 RSV-positive specimens from symptomatic patients diagnosed with RSV who presented to the Massachusetts General Hospital (MGH) and its outpatient practices in the Greater Boston Area. Genomic analysis of the resulting 77 genomes (54 with >80% coverage, and 23 with >5% coverage) demonstrated that the surge was driven by multiple lineages of RSV-A (91%; 70/77) and RSV-B (9%; 7/77). Phylogenetic analysis of all US RSV-A revealed 12 clades, 4 of which contained Massachusetts and Washington genomes. These clades individually had times to most recent common ancestor (tMRCA) between 2014 and 2017, and together had a tMRCA of 2009, suggesting that they emerged well before the COVID-19 pandemic. Similarly, the RSV-B genomes had a tMRCA between 2016 and 2019. We found that the RSV-A and RSV-B genomes in our sample did not differ statistically from the estimated clock rate of the larger phylogenetic tree (10.6 and 12.4 substitutions per year, respectively). In summary, the polyphyletic nature of viral genomes sequenced in the US during the autumn 2022 surge is inconsistent with the emergence of a single, highly transmissible causal RSV lineage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2023 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2023 Tipo del documento: Article