Relationships between Type 1 interferon signatures and clinical features of the new-onset lupus patients in Japan.
Mod Rheumatol
; 34(2): 346-351, 2024 Feb 26.
Article
en En
| MEDLINE
| ID: mdl-36695430
ABSTRACT
OBJECTIVES:
The objective of the study is to investigate the relationships between Type 1 interferon (T1-IFN) signatures and clinical characteristics of lupus patients.METHODS:
We examined 49 new-onset lupus patients who were diagnosed between 1999 and 2017. The patients treated with >10 mg of prednisolone or hydroxychloroquine were excluded from this study. Serum T1-IFN signatures were revealed by a functional reporter assay and standardized by recombinant IFN-α. Patient backgrounds, clinical findings, and treatments were retrospectively extracted from their electrical medical records. Clinical data were also available, including SLE Disease Activity Index of SLE patients on admission.RESULTS:
T1-IFN signatures of lupus patients closely correlated with lupus disease activities, such as SLE Disease Activity Index-2K, white blood cell, C3 levels, and the titre of double-strand DNA antibody. We found fever and acute lupus dermatitis closely associated with T1-IFN signature.CONCLUSIONS:
In lupus patients, fever and acute lupus dermatitis are good indicators of a strong T1-IFN signature.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Interferón Tipo I
/
Dermatitis
/
Lupus Eritematoso Sistémico
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Mod Rheumatol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón