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Reference intervals for thyroid biomarkers to enhance the assessment of thyroid status in childhood and adolescence.
Ferraro, Simona; Luconi, Ester; Calcaterra, Valeria; Cordaro, Erika; Bianchi, Alice; Cereda, Cristina; Zuccotti, Gianvincenzo; Kavsak, Peter; Plebani, Mario; Biganzoli, Elia Mario; Marano, Giuseppe; Boracchi, Patrizia.
Afiliación
  • Ferraro S; Center of Functional Genomics and Rare Diseases, Department of Pediatrics, Buzzi Children's Hospital, Milan, Italy.
  • Luconi E; Medical Statistics Unit, Department of Biomedical and Clinical Sciences L. Sacco, "Luigi Sacco" University Hospital, University of Milan, Milan, Italy.
  • Calcaterra V; Department of Internal Medicine, University of Pavia, Pavia, Italy.
  • Cordaro E; Pediatric Department, Buzzi Children's Hospital, Milan, Italy.
  • Bianchi A; Department of Internal Medicine, University of Pavia, Pavia, Italy.
  • Cereda C; Pediatric Department, Buzzi Children's Hospital, Milan, Italy.
  • Zuccotti G; Center of Functional Genomics and Rare Diseases, Department of Pediatrics, Buzzi Children's Hospital, Milan, Italy.
  • Kavsak P; Pediatric Department, Buzzi Children's Hospital, Milan, Italy.
  • Plebani M; Pediatric Department, Buzzi Children's Hospital, Milan, Italy.
  • Biganzoli EM; Department of Biomedical and Clinical Science, University of Milan, Milan, Italy.
  • Marano G; McMaster University, Hamilton, ON, Canada.
  • Boracchi P; Department of Medicine-DIMED, University of Padova, Padua, Italy.
Clin Chem Lab Med ; 61(7): 1309-1318, 2023 06 27.
Article en En | MEDLINE | ID: mdl-36704909
ABSTRACT

OBJECTIVES:

The determination of assay-dependent upper and lower reference limits (URL, LRL) of free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) during childhood and adolescence, is challenging.

METHODS:

Thyroid hormones were measured via the Abbott Alinity system in 502 euthyroid children partitioned in the following age groups ≤2, 2.1-10, and 10.1-18 years. The 97.5th and 2.5th percentiles (URL and LRL) were derived according to CLSI EP28- A3c guidelines. Quantile regression models were used to assess (a) 90% confidence intervals of the URL and LRL, (b) the effect of age on URL and LRL within each age class and on overall age range, (c) the difference between the URLs and LRLs estimated for each age partition with an estimate of the confidence interval divided by the reference interval being derived (CI/RI).

RESULTS:

The CI/RI for the LRLs are smaller as compared to the URLs, except for FT4 for the 2.1-10 years age group. Considering the CI/RI and the overlap between CIs across the three age groups, one single LRL might be considered for TSH, FT3 and FT4 between 0 and 18 years. However, for the URL, there was a noticeable decrease in the URL over the 3 age groups for all three biomarkers, with there being no overlap in CIs for the URL between the ≤2 vs. the 10.1-19 years age groups.

CONCLUSIONS:

A common LRL for TSH, FT4 and FT3 for patients aged ≤18 years may be utilized when these biomarkers are measured with the Alinity system. For the URLs the use of age-specific URLs for these biomarkers is recommended.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándula Tiroides / Tiroxina Límite: Adolescent / Child / Child, preschool / Humans Idioma: En Revista: Clin Chem Lab Med Asunto de la revista: QUIMICA CLINICA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2023 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándula Tiroides / Tiroxina Límite: Adolescent / Child / Child, preschool / Humans Idioma: En Revista: Clin Chem Lab Med Asunto de la revista: QUIMICA CLINICA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2023 Tipo del documento: Article País de afiliación: Italia
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