Retention behavior of short double-stranded oligonucleotide and its potential impurities by anion-exchange chromatography under non-denaturing conditions.

Togawa, Hiroyuki; Okubo, Takashi; Nonaka, Yumi; Yamaguchi, Takao; Obika, Satoshi

Togawa, Hiroyuki; Okubo, Takashi; Nonaka, Yumi; Yamaguchi, Takao; Obika, Satoshi.

Afiliación

Togawa H; Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan; CERI Hita, Chemicals Evaluation and Research Institute, Japan, 3-822 Ishii-machi, Hita, Oita 877-0061, Japan.
Okubo T; CERI Hita, Chemicals Evaluation and Research Institute, Japan, 3-822 Ishii-machi, Hita, Oita 877-0061, Japan.
Nonaka Y; CERI Kurume, Chemicals Evaluation and Research Institute, Japan, 3-2-7 Miyanojin, Kurume, Fukuoka 839-0801, Japan.
Yamaguchi T; Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Obika S; Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: obika@phs.osaka-u.ac.jp.

J Chromatogr A ; 1691: 463808, 2023 Feb 22.

Article en En | MEDLINE | ID: mdl-36706652

Asunto(s)

Oligonucleótidos; ARN Bicatenario; ARN Interferente Pequeño/química; Aniones; Cromatografía

Palabras clave

Anion-exchange chromatography; Double-stranded oligonucleotide; Non-denaturing chromatography; Oligonucleotide impurity; siRNA

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligonucleótidos / ARN Bicatenario Idioma: En Revista: J Chromatogr A Año: 2023 Tipo del documento: Article País de afiliación: Japón

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