Effects of antiresorptive medications on tooth root formation and tooth eruption in paediatric patients.
Orthod Craniofac Res
; 26 Suppl 1: 29-38, 2023 Dec.
Article
en En
| MEDLINE
| ID: mdl-36714970
ABSTRACT
Tooth eruption is a pivotal milestone for children's growth and development. This process involves with the formation of the tooth root, the periodontal ligament (PDL) and the alveolar bone, as the tooth crown penetrates the bone and gingiva to enter the oral cavity. This review aims to outline current knowledge of the adverse dental effects of antiresorptive medications. Recently, paediatric indications for antiresorptive medications, such as bisphosphonates (BPs), have emerged, and these agents are increasingly used in children and adolescents to cure pathological bone resorption associated with bone diseases and cancers. Since tooth eruption is accompanied by osteoclastic bone resorption, it is expected that the administration of antiresorptive medications during this period affects tooth development. Indeed, several articles studying human patient cohorts and animal models report the dental defects associated with the use of these antiresorptive medications. This review shows the summary of the possible factors related to tooth eruption and introduces the future research direction to understand the mechanisms underlying the dental defects caused by antiresorptive medications.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Erupción Dental
/
Resorción Ósea
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Animals
/
Child
/
Humans
Idioma:
En
Revista:
Orthod Craniofac Res
Asunto de la revista:
ODONTOLOGIA
/
ORTODONTIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos