Exosomal miR-3131 derived from endothelial cells with KRAS mutation promotes EndMT by targeting PICK1 in brain arteriovenous malformations.

He, Qiheng; Huo, Ran; Wang, Jie; Xu, Hongyuan; Zhao, Shaozhi; Zhang, Junze; Sun, Yingfan; Jiao, Yuming; Weng, Jiancong; Zhao, Jizong; Cao, Yong

He, Qiheng; Huo, Ran; Wang, Jie; Xu, Hongyuan; Zhao, Shaozhi; Zhang, Junze; Sun, Yingfan; Jiao, Yuming; Weng, Jiancong; Zhao, Jizong; Cao, Yong.

Afiliación

He Q; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Huo R; China National Clinical Research Center for Neurological Diseases, Beijing, China.
Wang J; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xu H; China National Clinical Research Center for Neurological Diseases, Beijing, China.
Zhao S; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhang J; China National Clinical Research Center for Neurological Diseases, Beijing, China.
Sun Y; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jiao Y; China National Clinical Research Center for Neurological Diseases, Beijing, China.
Weng J; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhao J; China National Clinical Research Center for Neurological Diseases, Beijing, China.
Cao Y; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

CNS Neurosci Ther ; 29(5): 1312-1324, 2023 05.

Article en En | MEDLINE | ID: mdl-36718590

Asunto(s)

Malformaciones Arteriovenosas Intracraneales; MicroARNs; Humanos; MicroARNs/genética; MicroARNs/metabolismo; Células Endoteliales de la Vena Umbilical Humana/metabolismo; Malformaciones Arteriovenosas Intracraneales/genética; Malformaciones Arteriovenosas Intracraneales/metabolismo; Mutación/genética; Encéfalo/metabolismo; Proteínas Proto-Oncogénicas p21(ras)/genética; Proteínas Proto-Oncogénicas p21(ras)/metabolismo; Proteínas Portadoras/genética; Proteínas Nucleares/genética

Palabras clave

Kras; PICK1; brain arteriovenous malformations; endothelial-mesenchymal transition; miR-3131; microenvironment

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Malformaciones Arteriovenosas Intracraneales / MicroARNs Límite: Humans Idioma: En Revista: CNS Neurosci Ther Asunto de la revista: NEUROLOGIA / TERAPEUTICA Año: 2023 Tipo del documento: Article País de afiliación: China

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