Genomic and Transcriptomic Characterization Revealed the High Sensitivity of Targeted Therapy and Immunotherapy in a Subset of Endometrial Stromal Sarcoma.

Kang, Nan; Zhang, Yinli; Guo, Shichao; Chen, Ran; Kong, Fangzhou; Wang, Shuchun; Yuan, Mingming; Chen, Rongrong; Shen, Danhua; Wang, Jianliu

Kang, Nan; Zhang, Yinli; Guo, Shichao; Chen, Ran; Kong, Fangzhou; Wang, Shuchun; Yuan, Mingming; Chen, Rongrong; Shen, Danhua; Wang, Jianliu.

Afiliación

Kang N; Department of Pathology, Peking University People's Hospital, Beijing, China.
Zhang Y; Department of Pathology, Peking University People's Hospital, Beijing, China.
Guo S; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chen R; Department of Pathology, Peking University People's Hospital, Beijing, China.
Kong F; Department of Pathology, Peking University People's Hospital, Beijing, China.
Wang S; Geneplus-Beijing, Beijing, China.
Yuan M; Geneplus-Beijing, Beijing, China.
Chen R; Geneplus-Beijing, Beijing, China.
Shen D; Department of Pathology, Peking University People's Hospital, Beijing, China.
Wang J; Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.

Cancer Res Treat ; 55(3): 978-991, 2023 Jul.

Article en En | MEDLINE | ID: mdl-36731460

Asunto(s)

Neoplasias Endometriales; Sarcoma Estromático Endometrial; Femenino; Humanos; Sarcoma Estromático Endometrial/genética; Sarcoma Estromático Endometrial/terapia; Sarcoma Estromático Endometrial/diagnóstico; Neoplasias Endometriales/tratamiento farmacológico; Neoplasias Endometriales/genética; Transcriptoma; Estudios Retrospectivos; Fosfatidilinositol 3-Quinasas/metabolismo; Factores de Transcripción/genética; Genómica; Inmunoterapia; Microambiente Tumoral/genética

Palabras clave

DNA-based panel sequencing; High-grade endometrial stromal sarcoma; Immunotherapy; Targeted therapy; Whole transcriptome sequencing

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Sarcoma Estromático Endometrial Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Cancer Res Treat Año: 2023 Tipo del documento: Article País de afiliación: China

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