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Predictive language comprehension in Parkinson's disease.
Aveni, Katharine; Ahmed, Juweiriya; Borovsky, Arielle; McRae, Ken; Jenkins, Mary E; Sprengel, Katherine; Fraser, J Alexander; Orange, Joseph B; Knowles, Thea; Roberts, Angela C.
Afiliación
  • Aveni K; Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, United States of America.
  • Ahmed J; Department of Psychology, Western University, London, ON, Canada.
  • Borovsky A; Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, United States of America.
  • McRae K; Department of Psychology, Western University, London, ON, Canada.
  • Jenkins ME; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
  • Sprengel K; Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, United States of America.
  • Fraser JA; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
  • Orange JB; Department of Ophthalmology, Western University, St. Jo122seph's Health Care, London, ON, Canada.
  • Knowles T; School of Communication Sciences and Disorders, Western University, London, ON, Canada.
  • Roberts AC; Canadian Centre for Activity and Aging, Western University, London, ON, Canada.
PLoS One ; 18(2): e0262504, 2023.
Article en En | MEDLINE | ID: mdl-36753529
Verb and action knowledge deficits are reported in persons with Parkinson's disease (PD), even in the absence of dementia or mild cognitive impairment. However, the impact of these deficits on combinatorial semantic processing is less well understood. Following on previous verb and action knowledge findings, we tested the hypothesis that PD impairs the ability to integrate event-based thematic fit information during online sentence processing. Specifically, we anticipated persons with PD with age-typical cognitive abilities would perform more poorly than healthy controls during a visual world paradigm task requiring participants to predict a target object constrained by the thematic fit of the agent-verb combination. Twenty-four PD and 24 healthy age-matched participants completed comprehensive neuropsychological assessments. We recorded participants' eye movements as they heard predictive sentences (The fisherman rocks the boat) alongside target, agent-related, verb-related, and unrelated images. We tested effects of group (PD/control) on gaze using growth curve models. There were no significant differences between PD and control participants, suggesting that PD participants successfully and rapidly use combinatory thematic fit information to predict upcoming language. Baseline sentences with no predictive information (e.g., Look at the drum) confirmed that groups showed equivalent sentence processing and eye movement patterns. Additionally, we conducted an exploratory analysis contrasting PD and controls' performance on low-motion-content versus high-motion-content verbs. This analysis revealed fewer predictive fixations in high-motion sentences only for healthy older adults. PD participants may adapt to their disease by relying on spared, non-action-simulation-based language processing mechanisms, although this conclusion is speculative, as the analyses of high- vs. low-motion items was highly limited by the study design. These findings provide novel evidence that individuals with PD match healthy adults in their ability to use verb meaning to predict upcoming nouns despite previous findings of verb semantic impairment in PD across a variety of tasks.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
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