Protein kinase C showcases allosteric control: activation of LRRK1.
Biochem J
; 480(3): 219-223, 2023 02 14.
Article
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| MEDLINE
| ID: mdl-36762701
ABSTRACT
Allosteric regulation of multi-domain protein kinases provides a common mechanism to acutely control kinase activity. Protein kinase C serves as a paradigm for multi-domain proteins whose activity is exquisitely tuned by interdomain conformational changes that keep the enzyme off in the absence of appropriate stimuli, but unleash activity in response to second messenger binding. Allosteric regulation of protein kinase C signaling has been optimized not just for itself Alessi and colleagues discover that protein kinase C phosphorylates LRRK1, a kinase with even more domains, at sites on its CORB GTPase domain to allosterically activate LRRK1.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteína Quinasa C
/
Transducción de Señal
/
Proteínas Serina-Treonina Quinasas
Idioma:
En
Revista:
Biochem J
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos