Dehydroepiandrosterone protects against oleic acid-triggered mitochondrial dysfunction to relieve oxidative stress and inflammation via activation of the AMPK-Nrf2 axis by targeting GPR30 in hepatocytes.

Yao, Yao; Wang, Huihui; Yang, Ying; Jiang, Zhihao; Ma, Haitian

Yao, Yao; Wang, Huihui; Yang, Ying; Jiang, Zhihao; Ma, Haitian.

Afiliación

Yao Y; Key Laboratory of Animal Physiology and Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; MOE Joint International Research Laboratory of Animal Health and food safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095,
Wang H; Key Laboratory of Animal Physiology and Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; MOE Joint International Research Laboratory of Animal Health and food safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095,
Yang Y; Key Laboratory of Animal Physiology and Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; MOE Joint International Research Laboratory of Animal Health and food safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095,
Jiang Z; Key Laboratory of Animal Physiology and Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; MOE Joint International Research Laboratory of Animal Health and food safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095,
Ma H; Key Laboratory of Animal Physiology and Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; MOE Joint International Research Laboratory of Animal Health and food safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095,

Mol Immunol ; 155: 110-123, 2023 03.

Article en En | MEDLINE | ID: mdl-36773597

Asunto(s)

Proteínas Quinasas Activadas por AMP; Ácido Oléico; Humanos; Animales; Femenino; Especies Reactivas de Oxígeno/metabolismo; Proteínas Quinasas Activadas por AMP/metabolismo; Ácido Oléico/efectos adversos; Ácido Oléico/metabolismo; Factor 2 Relacionado con NF-E2/metabolismo; FN-kappa B/metabolismo; Pollos; Estrés Oxidativo; Hepatocitos/metabolismo; Inflamación/metabolismo; Receptores Acoplados a Proteínas G/metabolismo; Deshidroepiandrosterona/farmacología

Palabras clave

AMPK-Nrf2 signaling pathway; Dehydroepiandrosterone; G-protein coupled estrogen receptor; Hepatocytes; Mitochondrial dysfunction

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Oléico / Proteínas Quinasas Activadas por AMP Límite: Animals / Female / Humans Idioma: En Revista: Mol Immunol Año: 2023 Tipo del documento: Article

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