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DNA Methylation Near CPT1A and Changes in Triglyceride-rich Lipoproteins in Response to Weight-loss Diet Interventions.
Li, Xiang; Shao, Xiaojian; Xue, Qiaochu; Kou, Minghao; Champagne, Catherine M; Koseva, Boryana S; Heianza, Yoriko; Grundberg, Elin; Bazzano, Lydia A; Bray, George A; Sacks, Frank M; Qi, Lu.
Afiliación
  • Li X; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.
  • Shao X; Digital Technologies Research Centre, National Research Council Canada, Ottawa, Ontario K1C 0R6, Canada.
  • Xue Q; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.
  • Kou M; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.
  • Champagne CM; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
  • Koseva BS; Department of Pediatrics, Genomic Medicine Center, Children's Mercy Kansas City, Kansas City, MO 64108, USA.
  • Heianza Y; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.
  • Grundberg E; Department of Pediatrics, Genomic Medicine Center, Children's Mercy Kansas City, Kansas City, MO 64108, USA.
  • Bazzano LA; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.
  • Bray GA; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
  • Sacks FM; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Qi L; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.
J Clin Endocrinol Metab ; 108(8): e542-e549, 2023 Jul 14.
Article en En | MEDLINE | ID: mdl-36800272
CONTEXT: Carnitine palmitoyltransferase-1A, encoded by the CPT1A gene, plays a key role in the oxidation of long-chain fatty acids in the mitochondria and may be important in triglyceride metabolism. Previous work has shown that high fat intake was negatively associated with CPT1A methylation and positively associated with CPT1A expression. OBJECTIVE: We aim to investigate the association of DNA methylation (DNAm) at the CPT1A gene with reductions in triglycerides and triglyceride-rich lipoproteins (TRLs) in response to weight-loss diet interventions. METHODS: The current study included 538 White participants, who were randomly assigned to 1 of 4 diets varying in macronutrient components. We defined the regional DNAm at CPT1A as the average methylation level over CpGs within 500 bp of the 3 triglyceride-related DNAm sites. RESULTS: Dietary fat intake significantly modified the association between baseline DNAm at CPT1A and 2-year changes in total plasma triglycerides, independent of concurrent weight loss. Among participants assigned to a low-fat diet, a higher regional DNAm level at CPT1A was associated with a greater reduction in total plasma triglycerides at 2 years (P = .01), compared with those assigned to a high-fat diet (P = .64) (P interaction = .018). Further investigation on lipids and apolipoproteins in very low-density lipoprotein (VLDL) revealed similar interaction patterns for 2-year changes in VLDL-triglycerides, VLDL-cholesterol, and VLDL-apolipoprotein B (P interaction = .009, .002, and .016, respectively), but not for VLDL-apoC-III (P interaction = .36). CONCLUSION: Participants with a higher regional DNAm level at CPT1A benefit more in long-term improvement in triglycerides, particularly in the TRLs and related apolipoproteins when consuming a low-fat weight-loss diet.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carnitina O-Palmitoiltransferasa / Metilación de ADN Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: J Clin Endocrinol Metab Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carnitina O-Palmitoiltransferasa / Metilación de ADN Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: J Clin Endocrinol Metab Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
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