Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice.
Science
; 379(6634): 826-833, 2023 02 24.
Article
en En
| MEDLINE
| ID: mdl-36821686
ABSTRACT
The intestinal microbiota is known to influence postnatal growth. We previously found that a strain of Lactiplantibacillus plantarum (strain LpWJL) buffers the adverse effects of chronic undernutrition on the growth of juvenile germ-free mice. Here, we report that LpWJL sustains the postnatal growth of malnourished conventional animals and supports both insulin-like growth factor-1 (IGF-1) and insulin production and activity. We have identified cell walls isolated from LpWJL, as well as muramyl dipeptide and mifamurtide, as sufficient cues to stimulate animal growth despite undernutrition. Further, we found that NOD2 is necessary in intestinal epithelial cells for LpWJL-mediated IGF-1 production and for postnatal growth promotion in malnourished conventional animals. These findings indicate that, coupled with renutrition, bacteria cell walls or purified NOD2 ligands have the potential to alleviate stunting.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_zoonosis
Asunto principal:
Lactobacillaceae
/
Desnutrición
/
Proteína Adaptadora de Señalización NOD2
/
Microbioma Gastrointestinal
/
Crecimiento
/
Intestinos
Tipo de estudio:
Prognostic_studies
Aspecto:
Determinantes_sociais_saude
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2023
Tipo del documento:
Article
País de afiliación:
República Checa