Lifestyle Factors, Genetic Risk, and Cardiovascular Disease Risk among Breast Cancer Survivors: A Prospective Cohort Study in UK Biobank.
Nutrients
; 15(4)2023 Feb 08.
Article
en En
| MEDLINE
| ID: mdl-36839222
ABSTRACT
BACKGROUND:
Evidence is limited regarding the association between lifestyles and cardiovascular disease (CVD), and the extent to which healthy lifestyles could offset the genetic risk of CVD in females with breast cancer (BC).METHODS:
Females diagnosed as BC, who were free of CVD at baseline, from UK Biobank were included. Five modifiable lifestyle factors were considered to calculate the healthy lifestyle score, namely body mass index (BMI), smoking, alcohol drinking, dietary habits, and physical activity. The polygenetic risk score (PRS) was derived for coronary heart disease (CHD), ischemic stroke (IS), and heart failure (HF).RESULTS:
In 13,348 female BC survivors, there were 986 CVD events (736 CHD, 165 IS, and 353 HF) over a median of 8.01 years of follow-up. Participants with 4-5 healthy lifestyle components were associated with a decreased risk of incident CVD (HR 0.50; 95%CI 0.37, 0.66), CHD (HR 0.49; 95%CI 0.35, 0.69), IS (HR 0.35; 95%CI 0.19, 0.65), and HF (HR 0.59; 95%CI 0.36, 0.97), compared with those with 0-1 lifestyle components. Evidence for the genetic-lifestyle interaction was observed for CHD (p = 0.034) and HF (p = 0.044). Among participants at high genetic risk, a healthy lifestyle was associated with a lower risk of CHD (HR 0.37; 95%CI 0.24, 0.56), IS (HR 0.37; 95%CI 0.15, 0.93) and HF (HR 0.39; 95%CI 0.21, 0.73).CONCLUSIONS:
Our findings suggest that BC survivors with a high genetic risk could benefit more from adherence to a healthy lifestyle in reducing CVD risk.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Enfermedades Cardiovasculares
/
Enfermedad Coronaria
/
Supervivientes de Cáncer
/
Insuficiencia Cardíaca
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Nutrients
Año:
2023
Tipo del documento:
Article
País de afiliación:
China