Modification of oestrogen signalling pathways influences cough induced by citric acid but not capsaicin in the animal model of both sexes.
Respir Physiol Neurobiol
; 312: 104039, 2023 06.
Article
en En
| MEDLINE
| ID: mdl-36842728
ABSTRACT
To clarify the role of oestrogen signalling and the role of oestrogen receptor alpha (ERα) in the cough pathways we performed a study in which coughing was observed in both sexes animal models after the treatment by selective ERα degrader fulvestrant (ICI 182-780) and inhibitor of oestrogen synthesis danazol. Degradation of ERα with the normal plasma oestrogen levels induced by fulvestrant, significantly augments the cough response of female but not male guinea pigs. These changes were observed in citric acid-induced cough. Female guinea pigs responded with an increased count of cough expulsions per challenge time and we also detected shorter cough latency. The capsaicin-induced cough did not change. A similar response was observed after danazol treatment, which decreased the plasma oestrogen level. Our results indicate that the transient receptor potential vanilloid-1 (TRPV1) channel-mediated cough is resistant to the hypoestrous state, while the citric acid-mediated cough is oestrogen-dependent and hypersensitive during the hypoestrous state.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Cítrico
/
Tos
Límite:
Animals
Idioma:
En
Revista:
Respir Physiol Neurobiol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Eslovaquia