JAK1/2 inhibitor ruxolitinib promotes the expansion and suppressive action of polymorphonuclear myeloid-derived suppressor cells via the JAK/STAT and ROS-MAPK/NF-&#954;B signalling pathways in acute graft-versus-host disease.

Cao, Yigeng; Wang, Jiali; Jiang, Shan; Lyu, Mengnan; Zhao, Fei; Liu, Jia; Wang, Mingyang; Pei, Xiaolei; Zhai, Weihua; Feng, Xiaoming; Feng, Sizhou; Han, Mingzhe; Xu, Yuanfu; Jiang, Erlie

JAK1/2 inhibitor ruxolitinib promotes the expansion and suppressive action of polymorphonuclear myeloid-derived suppressor cells via the JAK/STAT and ROS-MAPK/NF-κB signalling pathways in acute graft-versus-host disease.

Cao, Yigeng; Wang, Jiali; Jiang, Shan; Lyu, Mengnan; Zhao, Fei; Liu, Jia; Wang, Mingyang; Pei, Xiaolei; Zhai, Weihua; Feng, Xiaoming; Feng, Sizhou; Han, Mingzhe; Xu, Yuanfu; Jiang, Erlie.

Afiliación

Cao Y; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China.
Wang J; Tianjin Institutes of Health Science Tianjin China.
Jiang S; Hematopoietic Stem Cell Transplantation Center, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China.
Lyu M; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China.
Zhao F; Tianjin Institutes of Health Science Tianjin China.
Liu J; Hematopoietic Stem Cell Transplantation Center, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China.
Wang M; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China.
Pei X; Tianjin Institutes of Health Science Tianjin China.
Zhai W; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China.
Feng X; Tianjin Institutes of Health Science Tianjin China.
Feng S; Hematopoietic Stem Cell Transplantation Center, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China.
Han M; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China.
Xu Y; Tianjin Institutes of Health Science Tianjin China.
Jiang E; Hematopoietic Stem Cell Transplantation Center, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China.

Clin Transl Immunology ; 12(2): e1441, 2023.

Article en En | MEDLINE | ID: mdl-36855558

Palabras clave

JAK/STAT pathway; ROS; acute graftversushost disease; myeloidderived suppressor cells

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Transl Immunology Año: 2023 Tipo del documento: Article