CRISPR/dCas9-KRAB-Mediated Suppression of <i>S100b</i> Restores p53-Mediated Apoptosis in Melanoma Cells.

Roy Choudhury, Samrat; Heflin, Billie; Taylor, Erin; Koss, Brian; Avaritt, Nathan L; Tackett, Alan J

CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells.

Roy Choudhury, Samrat; Heflin, Billie; Taylor, Erin; Koss, Brian; Avaritt, Nathan L; Tackett, Alan J.

Afiliación

Roy Choudhury S; Pediatric Hematology-Oncology, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.
Heflin B; Department of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Taylor E; Department of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Koss B; Department of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Avaritt NL; Department of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Tackett AJ; Department of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Cells ; 12(5)2023 02 24.

Article en En | MEDLINE | ID: mdl-36899866

Asunto(s)

Melanoma; Proteína p53 Supresora de Tumor; Animales; Humanos; Ratones; Apoptosis; Melanoma/patología; Regiones Promotoras Genéticas; Subunidad beta de la Proteína de Unión al Calcio S100/metabolismo; Factores de Transcripción/metabolismo; Proteína p53 Supresora de Tumor/metabolismo

Palabras clave

CRISPR; S100b; apoptosis; cell death; dCas9-KRAB; melanoma

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_malignant_skin_melanoma Asunto principal: Proteína p53 Supresora de Tumor / Melanoma Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cells Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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