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Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer.
Patterson-Fortin, Jeffrey; Jadhav, Heta; Pantelidou, Constantia; Phan, Tin; Grochala, Carter; Mehta, Anita K; Guerriero, Jennifer L; Wulf, Gerburg M; Wolpin, Brian M; Stanger, Ben Z; Aguirre, Andrew J; Cleary, James M; D'Andrea, Alan D; Shapiro, Geoffrey I.
Afiliación
  • Patterson-Fortin J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
  • Jadhav H; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
  • Pantelidou C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
  • Phan T; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
  • Grochala C; Bayer Pharmaceuticals, Cambridge, MA, USA.
  • Mehta AK; Department of Radiation Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.
  • Guerriero JL; Department of Radiation Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.
  • Wulf GM; Arpeggio, Boulder, CO, USA.
  • Wolpin BM; Department of Surgical Oncology and Harvard Medical School, Brigham and Women's Hospital, Boston, MA, 02115, USA.
  • Stanger BZ; Sanofi, Cambridge, MA, USA.
  • Aguirre AJ; Department of Surgical Oncology and Harvard Medical School, Brigham and Women's Hospital, Boston, MA, 02115, USA.
  • Cleary JM; Department of Medicine, Division of Hematology-Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
  • D'Andrea AD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
  • Shapiro GI; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Nat Commun ; 14(1): 1390, 2023 03 13.
Article en En | MEDLINE | ID: mdl-36914658
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_endocrine_disorders / 6_pancreatic_cancer Asunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / ADN Polimerasa Dirigida por ADN Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_endocrine_disorders / 6_pancreatic_cancer Asunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / ADN Polimerasa Dirigida por ADN Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos