Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1.
J Ginseng Res
; 47(2): 210-217, 2023 Mar.
Article
en En
| MEDLINE
| ID: mdl-36926614
ABSTRACT
Background:
Effects of the major ginsenoside Rg1 on mammalian longevity and physical vitality are rarely reported.Purpose:
To examine longevity, tumor, and spontaneous locomotor activity in rats consuming Rg1.Methods:
A total of 138 Wistar rats were randomized into 2 groups control (N = 69) and Rg1 (N = 69). Rg1 (0.1 mg/kg per day) were orally supplemented from 6 months of age until natural death. Spontaneous mobility was measured by video-tracking together with body composition (dual energy x-ray absorptiometry) and inflammation markers at 5, 14, 21, and 28 months of age.Results:
No significant differences in longevity (control 706 days; Rg1 651 days, p = 0.77) and tumor incidence (control 19%; Rg1 12%, p = 0.24) were observed between the two groups. Movement distance in the control group declined significantly by â¼60% at 21 months of age, together with decreased TNF-α (p = 0.01) and increased IL-10 (p = 0.02). However, the movement distance in the Rg1 group was maintained â¼50% above the control groups (p = 0.01) at 21 months of age with greater magnitudes of TNF-α decreases and IL-10 increases. Glucose, insulin, and body composition (bone, muscle and fat percentages) were similar for both groups during the entire observation period.Conclusion:
The results of the study suggest a delay age-dependent decline in physical vitality during late life by lifelong Rg1 consumption. This improvement is associated with inflammatory modulation. Significant effects of Rg1 on longevity and tumorigenesis were not observed.
Dual-energy x-ray absorptiometry, (DEXA); Ginseng; High-fructose corn syrup, (HFCS); IL-10; Inflammation; Institutional Animal Care and Use Committee, (IACUC); Interleukin-10, (IL-10); Muscle mass; Obesity; Oxidized LDL; Oxidized low density lipoprotein, (oxidized LDL); Standard error, (SE); TNF-α; Tumor necrosis factor-α, (TNF-α); Two-way analysis of variance, (ANOVA)
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
J Ginseng Res
Año:
2023
Tipo del documento:
Article
País de afiliación:
Taiwán