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Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections.
Le, Tram; Nang, Sue C; Zhao, Jinxin; Yu, Heidi H; Li, Jian; Gill, Jason J; Liu, Mei; Aslam, Saima.
Afiliación
  • Le T; Center for Phage Technology, Texas A&M AgriLife Research, Texas A&M University, College Station, Texas, USA.
  • Nang SC; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA.
  • Zhao J; Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.
  • Yu HH; Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.
  • Li J; Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.
  • Gill JJ; Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.
  • Liu M; Center for Phage Technology, Texas A&M AgriLife Research, Texas A&M University, College Station, Texas, USA.
  • Aslam S; Department of Animal Science, Texas A&M University, College Station, Texas, USA.
Antimicrob Agents Chemother ; 67(4): e0003723, 2023 04 18.
Article en En | MEDLINE | ID: mdl-36975787
ABSTRACT
Recurrent urinary tract infections (rUTI) are common in kidney transplant recipients (KTR) and are associated with multidrug resistance and increased morbidity/mortality. Novel antibiotic alternatives to reduce UTI recurrence are critically needed. We describe a case of rUTI due to extended spectrum beta lactamase (ESBL) Klebsiella pneumoniae in a KTR that was treated successfully with 4 weeks of adjunctive intravenous bacteriophage therapy alone, without concomitant antibiotics, and with no recurrence in a year of follow-up.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND / 4_TD / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 3_neglected_diseases / 3_zoonosis / 4_antimicrobial_resistance / 6_other_malignant_neoplasms Asunto principal: Infecciones Urinarias / Beta-Lactamasas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND / 4_TD / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 3_neglected_diseases / 3_zoonosis / 4_antimicrobial_resistance / 6_other_malignant_neoplasms Asunto principal: Infecciones Urinarias / Beta-Lactamasas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos