Current perspectives on resistance to chimeric antigen receptor T-cell therapy and strategies to improve efficacy in B-cell lymphoma.

Ong, Shin Yeu; Chen, Yunxin; Tan, Melinda Si Yun; Ho, Aloysius Yew Leng; Hwang, William Ying Khee; Lim, Francesca Lorraine Wei Inng

Ong, Shin Yeu; Chen, Yunxin; Tan, Melinda Si Yun; Ho, Aloysius Yew Leng; Hwang, William Ying Khee; Lim, Francesca Lorraine Wei Inng.

Afiliación

Ong SY; Department of Haematology, Singapore General Hospital, Singapore, Singapore.
Chen Y; Department of Haematology, Singapore General Hospital, Singapore, Singapore.
Tan MSY; Department of Haematology, Singapore General Hospital, Singapore, Singapore.
Ho AYL; Department of Haematology, Singapore General Hospital, Singapore, Singapore.
Hwang WYK; Department of Haematology, Singapore General Hospital, Singapore, Singapore.
Lim FLWI; Division of Medical Oncology, National Cancer Centre, Singapore, Singapore.

Eur J Haematol ; 112(2): 144-152, 2024 Feb.

Article en En | MEDLINE | ID: mdl-36987995

Asunto(s)

Linfoma de Células B; Receptores Quiméricos de Antígenos; Humanos; Inmunoterapia Adoptiva/efectos adversos; Receptores Quiméricos de Antígenos/genética; Receptores de Antígenos de Linfocitos T/genética; Antígenos CD19; Linfoma de Células B/terapia; Recurrencia; Tratamiento Basado en Trasplante de Células y Tejidos; Microambiente Tumoral

Palabras clave

B-cell lymphoma; CD19; T cell exhaustion; antigen escape; chimeric antigen receptor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células B / Receptores Quiméricos de Antígenos Límite: Humans Idioma: En Revista: Eur J Haematol Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Singapur

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