Effects of a high-fat diet on rat epididymis.
J Exp Zool A Ecol Integr Physiol
; 339(6): 535-544, 2023 07.
Article
en En
| MEDLINE
| ID: mdl-37009779
ABSTRACT
The epididymis plays an essential role in reproduction, promoting sperm cell maturation. In this study, we investigated the effects of a high-fat diet (HFD) in the three regions of the epididymis of rats, including caput, corpus, and cauda. Our results showed an increase in malondialdehyde and a decrease in superoxide dismutase, which indicated an increase in oxidative stress in all segments of the epididymis. The cellular response mechanisms were mostly detected in the corpus/cauda regions, which showed an increase in apoptosis, probably for eliminating dysfunctional cells arising from HFD-induced oxidative stress, and a decrease in mitophagy. Additionally, an increase in lipophagy to prevent lipid accumulation and a decrease in cell proliferation were recorded in the corpus.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Semen
/
Espermatozoides
Límite:
Animals
Idioma:
En
Revista:
J Exp Zool A Ecol Integr Physiol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Italia