Stereogenic-at-Cobalt(III) Complex Catalyzed Halocyclization of Alkynes: Enantioselective Access to Axially Chiral <i>ortho</i>-Halo-C2-indoles.

Yao, Chuan-Zhi; Xie, Zu-Kui; Wang, Jie-Yue; Zhang, Jia-Yu; Zhao, Zi-Yuan; Li, Qiankun; Yu, Jie

Stereogenic-at-Cobalt(III) Complex Catalyzed Halocyclization of Alkynes: Enantioselective Access to Axially Chiral ortho-Halo-C2-indoles.

Yao, Chuan-Zhi; Xie, Zu-Kui; Wang, Jie-Yue; Zhang, Jia-Yu; Zhao, Zi-Yuan; Li, Qiankun; Yu, Jie.

Afiliación

Yao CZ; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.
Xie ZK; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.
Wang JY; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.
Zhang JY; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.
Zhao ZY; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.
Li Q; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.
Yu J; Department of Applied Chemistry, Anhui Agricultural University, Hefei 230036, China.

J Org Chem ; 88(9): 6146-6158, 2023 May 05.

Article en En | MEDLINE | ID: mdl-37022671

ABSTRACT

ABSTRACT

Here, we report an anionic stereogenic-at-cobalt(III) complex catalysis strategy for the enantioselective halocyclization of ortho-alkynylanilines using N-halosuccinimide (NXS) as the halogen source. This protocol provides a distinct atroposelective approach to access the axially chiral ortho-halo-C2-indole skeletons in excellent yields with good to high enantioselectivities (up to 99% yield, 991 er).

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2023 Tipo del documento: Article País de afiliación: China