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Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents - Design, synthesis, structural studies and pharmacological profiling.
Stepnicki, Piotr; Targowska-Duda, Katarzyna M; Martínez, Antón L; Zieba, Agata; Wronikowska-Denysiuk, Olga; Wróbel, Martyna Z; Bartyzel, Agata; Trzpil, Alicja; Wróbel, Tomasz M; Chodkowski, Andrzej; Mirecka, Karolina; Karcz, Tadeusz; Szczepanska, Katarzyna; Loza, Maria I; Budzynska, Barbara; Turlo, Jadwiga; Handzlik, Jadwiga; Fornal, Emilia; Poleszak, Ewa; Castro, Marián; Kaczor, Agnieszka A.
Afiliación
  • Stepnicki P; Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodzki St., PL-20093, Lublin, Poland. Electronic address: piotrstepnicki93@gmail.com.
  • Targowska-Duda KM; Department of Biopharmacy, Faculty of Pharmacy, Medical University of Lublin, 4A Chodzki St., PL-20093, Lublin, Poland.
  • Martínez AL; Department of Pharmacology, Universidade de Santiago de Compostela, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Avda de Barcelona, E-15782, Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana s/n, E-15
  • Zieba A; Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodzki St., PL-20093, Lublin, Poland.
  • Wronikowska-Denysiuk O; Independent Laboratory of Behavioral Studies, Biomedical Sciences, Faculty of Biomedicine, Medical University of Lublin, 4A Chodzki St., PL-20093, Lublin, Poland.
  • Wróbel MZ; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097, Warszawa, Poland.
  • Bartyzel A; Department of General and Coordination Chemistry and Crystallography, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University in Lublin, Maria Curie-Sklodowska Sq. 2, 20-031, Lublin, Poland.
  • Trzpil A; Department of Bioanalytics, Dietetics and Bioanalytics, Faculty of Biomedicine, Medical University of Lublin, Jaczewskiego 8b St., 20-090, Lublin, Poland.
  • Wróbel TM; Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodzki St., PL-20093, Lublin, Poland.
  • Chodkowski A; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097, Warszawa, Poland.
  • Mirecka K; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097, Warszawa, Poland.
  • Karcz T; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL-30-688, Kraków, Poland.
  • Szczepanska K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL-30-688, Kraków, Poland.
  • Loza MI; Department of Pharmacology, Universidade de Santiago de Compostela, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Avda de Barcelona, E-15782, Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana s/n, E-15
  • Budzynska B; Independent Laboratory of Behavioral Studies, Biomedical Sciences, Faculty of Biomedicine, Medical University of Lublin, 4A Chodzki St., PL-20093, Lublin, Poland.
  • Turlo J; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097, Warszawa, Poland.
  • Handzlik J; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL-30-688, Kraków, Poland.
  • Fornal E; Department of Bioanalytics, Dietetics and Bioanalytics, Faculty of Biomedicine, Medical University of Lublin, Jaczewskiego 8b St., 20-090, Lublin, Poland.
  • Poleszak E; Department of Applied and Social Pharmacy, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki St., PL-20093, Lublin, Poland.
  • Castro M; Department of Pharmacology, Universidade de Santiago de Compostela, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Avda de Barcelona, E-15782, Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana s/n, E-15
  • Kaczor AA; Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodzki St., PL-20093, Lublin, Poland; School of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland. El
Eur J Med Chem ; 252: 115285, 2023 Apr 05.
Article en En | MEDLINE | ID: mdl-37027998
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Antipsicóticos Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Antipsicóticos Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article