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Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1-a]isoindole and Species Differences in Glucuronidation.
Wang, Shuai; Ma, Shuguang; Chen, Eugene; Wang, Jing; Le, Hoa; Hanlon, Steven Paul; Binder, Martin; Lee, Wendy; Khojasteh, S Cyrus; Salphati, Laurent.
Afiliación
  • Wang S; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (S.W., E.C., J.W., H.L., W.L., S.C.K., L.S.); Pliant Therapeutics, South San Francisco, California (S.M.); and Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd, Basel, Switzerland (S.P.H., M.B.).
  • Ma S; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (S.W., E.C., J.W., H.L., W.L., S.C.K., L.S.); Pliant Therapeutics, South San Francisco, California (S.M.); and Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd, Basel, Switzerland (S.P.H., M.B.).
  • Chen E; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (S.W., E.C., J.W., H.L., W.L., S.C.K., L.S.); Pliant Therapeutics, South San Francisco, California (S.M.); and Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd, Basel, Switzerland (S.P.H., M.B.).
  • Wang J; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (S.W., E.C., J.W., H.L., W.L., S.C.K., L.S.); Pliant Therapeutics, South San Francisco, California (S.M.); and Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd, Basel, Switzerland (S.P.H., M.B.).
  • Le H; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (S.W., E.C., J.W., H.L., W.L., S.C.K., L.S.); Pliant Therapeutics, South San Francisco, California (S.M.); and Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd, Basel, Switzerland (S.P.H., M.B.).
  • Hanlon SP; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (S.W., E.C., J.W., H.L., W.L., S.C.K., L.S.); Pliant Therapeutics, South San Francisco, California (S.M.); and Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd, Basel, Switzerland (S.P.H., M.B.).
  • Binder M; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (S.W., E.C., J.W., H.L., W.L., S.C.K., L.S.); Pliant Therapeutics, South San Francisco, California (S.M.); and Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd, Basel, Switzerland (S.P.H., M.B.).
  • Lee W; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (S.W., E.C., J.W., H.L., W.L., S.C.K., L.S.); Pliant Therapeutics, South San Francisco, California (S.M.); and Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd, Basel, Switzerland (S.P.H., M.B.).
  • Khojasteh SC; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (S.W., E.C., J.W., H.L., W.L., S.C.K., L.S.); Pliant Therapeutics, South San Francisco, California (S.M.); and Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd, Basel, Switzerland (S.P.H., M.B.).
  • Salphati L; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California (S.W., E.C., J.W., H.L., W.L., S.C.K., L.S.); Pliant Therapeutics, South San Francisco, California (S.M.); and Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd, Basel, Switzerland (S.P.H., M.B.) salphat
Drug Metab Dispos ; 51(7): 862-872, 2023 Jul.
Article en En | MEDLINE | ID: mdl-37059472
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Indolamina-Pirrol 2,3,-Dioxigenasa / Isoindoles Límite: Animals / Humans Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Indolamina-Pirrol 2,3,-Dioxigenasa / Isoindoles Límite: Animals / Humans Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article