Structural basis for Fc receptor recognition of immunoglobulin M.
Nat Struct Mol Biol
; 30(7): 1033-1039, 2023 07.
Article
en En
| MEDLINE
| ID: mdl-37095205
ABSTRACT
Immunoglobulin Fc receptors are cell surface transmembrane proteins that bind to the Fc constant region of antibodies and play critical roles in regulating immune responses by activation of immune cells, clearance of immune complexes and regulation of antibody production. FcµR is the immunoglobulin M (IgM) antibody isotype-specific Fc receptor involved in the survival and activation of B cells. Here we reveal eight binding sites for the human FcµR immunoglobulin domain on the IgM pentamer by cryogenic electron microscopy. One of the sites overlaps with the binding site for the polymeric immunoglobulin receptor (pIgR), but a different mode of FcµR binding explains its antibody isotype specificity. Variation in FcµR binding sites and their occupancy reflects the asymmetry of the IgM pentameric core and the versatility of FcµR binding. The complex explains engagement with polymeric serum IgM and the monomeric IgM B-cell receptor (BCR).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Receptores Fc
Límite:
Humans
Idioma:
En
Revista:
Nat Struct Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2023
Tipo del documento:
Article
País de afiliación:
Reino Unido