Viral sponges sequester nucleotide signals to inactivate immunity.

Richmond-Buccola, Desmond; Kranzusch, Philip J

Richmond-Buccola, Desmond; Kranzusch, Philip J.

Afiliación

Richmond-Buccola D; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Kranzusch PJ; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: philip_kranzusch@dfci.harvard.edu.

Trends Microbiol ; 31(6): 552-553, 2023 06.

Article en En | MEDLINE | ID: mdl-37100632

RESUMEN

Bacteria synthesize specialized nucleotide signals to control anti-phage defense. Two papers - by Huiting et al. and Jenson et al. - now reveal that bacteriophages encode protein 'sponges' that sequester cyclic oligonucleotide immune signals and inactivate host antiviral immunity.

Asunto(s)

Bacteriófagos; Nucleótidos; Nucleotidiltransferasas/metabolismo; Bacterias/metabolismo; Bacteriófagos/genética; Bacteriófagos/metabolismo; Proteínas Bacterianas/metabolismo

Palabras clave

CBASS; CD-NTase; anti-phage defense; cGAS; nucleotide second messenger

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacteriófagos / Nucleótidos Idioma: En Revista: Trends Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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