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Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids.
Papsdorf, Katharina; Miklas, Jason W; Hosseini, Amir; Cabruja, Matias; Morrow, Christopher S; Savini, Marzia; Yu, Yong; Silva-García, Carlos G; Haseley, Nicole R; Murphy, Luke Meraz; Yao, Pallas; de Launoit, Elisa; Dixon, Scott J; Snyder, Michael P; Wang, Meng C; Mair, William B; Brunet, Anne.
Afiliación
  • Papsdorf K; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Miklas JW; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Hosseini A; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Cabruja M; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Morrow CS; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Savini M; Department of Molecular and Human Genetics, Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.
  • Yu Y; Department of Molecular and Human Genetics, Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.
  • Silva-García CG; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.
  • Haseley NR; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Murphy LM; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Yao P; Department of Genetics, Stanford University, Stanford, CA, USA.
  • de Launoit E; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Dixon SJ; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Snyder MP; Department of Biology, Stanford University, Stanford, CA, USA.
  • Wang MC; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Mair WB; Department of Molecular and Human Genetics, Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.
  • Brunet A; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Nat Cell Biol ; 25(5): 672-684, 2023 05.
Article en En | MEDLINE | ID: mdl-37127715
Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an organelle network involving lipid droplets and peroxisomes is critical for MUFA-induced longevity in Caenorhabditis elegans. MUFAs upregulate the number of lipid droplets in fat storage tissues. Increased lipid droplet number is necessary for MUFA-induced longevity and predicts remaining lifespan. Lipidomics datasets reveal that MUFAs also modify the ratio of membrane lipids and ether lipids-a signature associated with decreased lipid oxidation. In agreement with this, MUFAs decrease lipid oxidation in middle-aged individuals. Intriguingly, MUFAs upregulate not only lipid droplet number but also peroxisome number. A targeted screen identifies genes involved in the co-regulation of lipid droplets and peroxisomes, and reveals that induction of both organelles is optimal for longevity. Our study uncovers an organelle network involved in lipid homeostasis and lifespan regulation, opening new avenues for interventions to delay aging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peroxisomas / Longevidad Límite: Animals / Humans / Middle aged Idioma: En Revista: Nat Cell Biol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peroxisomas / Longevidad Límite: Animals / Humans / Middle aged Idioma: En Revista: Nat Cell Biol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos