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Nano-selenium relieved hepatic and renal oxidative damage in hypothyroid rats.
Hosseini, Mahmoud; Behehsti, Farimah; Marefati, Narges; Anaeigoudari, Akbar.
Afiliación
  • Hosseini M; Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Behehsti F; Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
  • Marefati N; Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Iran.
  • Anaeigoudari A; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Physiol Rep ; 11(9): e15682, 2023 05.
Article en En | MEDLINE | ID: mdl-37144592
Hypothyroidism can induce oxidative stress. Nano-selenium (Nano Sel) has antioxidant effects. The current research explored Nano Sel effects on hepatic and renal oxidative damage induced by hypothyroidism in rats. Animals were grouped into (1) Control; (2) Propylthiouracil (PTU) group which received water mixed with 0.05% of PTU; (3) PTU-Nano Sel 50; (4) PTU-Nano Sel 100; and (5) PTU-Nano Sel 150. Besides PTU, the PTU-Nano Sel groups were treated with 50, 100, or 150 µg/kg of Nano Sel intraperitoneally. Treatments were done for 6 weeks. The serum level of T4, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), albumin, total protein, creatinine, and blood urea nitrogen (BUN) was evaluated. Malondialdehyde (MDA) and total thiol concentration and the activity of catalase (CAT) and superoxide dismutase (SOD) in hepatic and renal tissues also were checked. Hypothyroidism induced by PTU significantly increased AST, ALT, ALP, creatinine, BUN, and MDA concentration and noticeably reduced albumin, total protein, total thiol level, and SOD and CAT activity. Administration of Nano Sel ameliorated the adverse effects of hypothyroidism on liver and kidney function. Nano Sel applied protective effects against hepatic and renal damage resulting from hypothyroidism via ameliorating the oxidative stress status. More cellular and molecular experiments need to be done to understand the exact mechanisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selenio / Hipotiroidismo Límite: Animals Idioma: En Revista: Physiol Rep Año: 2023 Tipo del documento: Article País de afiliación: Irán

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selenio / Hipotiroidismo Límite: Animals Idioma: En Revista: Physiol Rep Año: 2023 Tipo del documento: Article País de afiliación: Irán
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