Anxiety, mood, and substance use disorders in adult men and women with and without attention-deficit/hyperactivity disorder: A substantive and methodological overview.
Neurosci Biobehav Rev
; 151: 105209, 2023 08.
Article
en En
| MEDLINE
| ID: mdl-37149075
ABSTRACT
Knowledge on psychiatric comorbidity in adult ADHD is essential for prevention, detection, and treatment of these conditions. This review (1) focuses on large studies (n > 10,000; surveys, claims data, population registries) to identify (a) overall, (b) sex- and (c) age-specific patterns of comorbidity of anxiety disorders (ADs), major depressive disorder (MDD), bipolar disorder (BD) and substance use disorders (SUDs) in adults with ADHD relative to adults without ADHD; and (2) describes methodological challenges relating to establishing comorbidity in ADHD in adults as well as priorities for future research. Meta-analyses (ADHD n = 550,748; no ADHD n = 14,546,814) yielded pooled odds ratios of 5.0(CI3.29-7.46) for ADs, 4.5(CI2.44-8.34) for MDD, 8.7(CI5.47-13.89) for BD and 4.6(CI2.72-7.80) for SUDs, indicating strong differences in adults with compared to adults without ADHD. Moderation by sex was not found high comorbidity held for both men and women with sex-specific patterns as in the general population higher prevalences of ADs, MDD and BD in women and a higher prevalence of SUDs in men. Insufficient data on different phases of the adult lifespan prevented conclusions on developmental changes in comorbidity. We discuss methodological challenges, knowledge gaps, and future research priorities.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_sustancias_psicoativas
Asunto principal:
Trastorno por Déficit de Atención con Hiperactividad
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Trastornos Relacionados con Sustancias
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Trastorno Depresivo Mayor
Tipo de estudio:
Overview
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Risk_factors_studies
/
Systematic_reviews
Límite:
Adult
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Neurosci Biobehav Rev
Año:
2023
Tipo del documento:
Article