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Prevalence and incidence of depressive symptoms and diagnosis of depression as associated with elevated amyloid among Medicare beneficiaries with cognitive impairment.
Bélanger, Emmanuelle; Jutkowitz, Eric; Shewmaker, Peter; Van Houtven, Courtney H; Burke, James R; Plassman, Brenda L; Shepherd-Banigan, Megan; Couch, Elyse; Mills, Caroline; Wetle, Terrie T.
Afiliación
  • Bélanger E; Center for Gerontology and Healthcare Research, Brown University, School of Public Health, Providence, RI, USA; Department of Health Services, Policy & Practice, Brown University, School of Public Health, Providence, RI, USA. Electronic address: emmanuelle_belanger@brown.edu.
  • Jutkowitz E; Center for Gerontology and Healthcare Research, Brown University, School of Public Health, Providence, RI, USA; Department of Health Services, Policy & Practice, Brown University, School of Public Health, Providence, RI, USA.
  • Shewmaker P; Center for Gerontology and Healthcare Research, Brown University, School of Public Health, Providence, RI, USA.
  • Van Houtven CH; Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA; Center of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Health Care System, Durham, NC, USA.
  • Burke JR; Department of Neurology, Duke University School of Medicine, Durham, NC, USA.
  • Plassman BL; Department of Neurology, Duke University School of Medicine, Durham, NC, USA; Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA.
  • Shepherd-Banigan M; Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA; Center of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Health Care System, Durham, NC, USA.
  • Couch E; Center for Gerontology and Healthcare Research, Brown University, School of Public Health, Providence, RI, USA.
  • Mills C; Center for Gerontology and Healthcare Research, Brown University, School of Public Health, Providence, RI, USA.
  • Wetle TT; Center for Gerontology and Healthcare Research, Brown University, School of Public Health, Providence, RI, USA; Department of Health Services, Policy & Practice, Brown University, School of Public Health, Providence, RI, USA.
J Affect Disord ; 334: 293-296, 2023 08 01.
Article en En | MEDLINE | ID: mdl-37150216
ABSTRACT

BACKGROUND:

Depression and cognitive impairment commonly co-occur, and it has been hypothesized that the two share pathological processes. Our objective for this study was to determine the relationship between elevated ß-amyloid level and the prevalence and incidence of depressive symptoms and diagnosed depression over two years among fee-for-service Medicare beneficiaries with cognitive impairment.

METHODS:

We utilized data from the CARE-IDEAS cohort study (N = 2078) including two measures of depressive symptoms (PHQ-2) and administrative claims data to identify pre-scan and incident depression diagnosis in subsample of fee-for-service Medicare beneficiaries (N = 1443). We used descriptive statistics and Poisson regression models with robust covariance.

RESULTS:

Beneficiaries whose scan results indicated not-elevated ß-amyloid were significantly more likely to have been diagnosed with depression pre-scan (46.4 % vs. 33.1 %). There was no significant association between elevated amyloid and the incidence of depressive symptoms or diagnosed depression.

LIMITATIONS:

The sample was limited to Medicare beneficiaries with cognitive impairment. Race/ethnic composition and education levels were not representative of the general population and there was substantial loss to follow-up. Mixed depressive / anxious episodes were captured as diagnoses of depression, potentially overestimating depression in this population.

CONCLUSIONS:

There was a high prevalence and incidence of diagnosed depression in this cohort of Medicare beneficiaries, but the incidence of depressive symptoms and diagnosed depression was not associated with elevated ß-amyloid.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicare / Disfunción Cognitiva Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans País/Región como asunto: America do norte Idioma: En Revista: J Affect Disord Año: 2023 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicare / Disfunción Cognitiva Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans País/Región como asunto: America do norte Idioma: En Revista: J Affect Disord Año: 2023 Tipo del documento: Article
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