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Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus.
Furey, Colleen; Ye, Naiqing; Kercher, Lisa; DeBeauchamp, Jennifer; Crumpton, Jeri Carol; Jeevan, Trushar; Patton, Christopher; Franks, John; Alameh, Mohamad-Gabriel; Fan, Steven H Y; Phan, Anthony T; Hunter, Christopher A; Webby, Richard J; Weissman, Drew; Hensley, Scott E.
Afiliación
  • Furey C; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Ye N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Kercher L; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • DeBeauchamp J; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Crumpton JC; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Jeevan T; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Patton C; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Franks J; Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38105, USA.
  • Alameh MG; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Fan SHY; Infectious Disease Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Phan AT; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Hunter CA; Acuitas Therapeutics, Vancouver, BC, CAN.
  • Webby RJ; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Weissman D; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Hensley SE; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
bioRxiv ; 2023 Apr 30.
Article en En | MEDLINE | ID: mdl-37162920
Highly pathogenic avian influenza viruses from H5 clade 2.3.4.4b are circulating at unprecedently high levels in wild and domestic birds and have the potential to adapt to humans. We generated an mRNA lipid nanoparticle (LNP) vaccine encoding the hemagglutinin (HA) glycoprotein from a clade 2.3.4.4b H5 isolate. We show that the vaccine is immunogenic in mice and ferrets and prevents morbidity and mortality of ferrets following 2.3.4.4b H5N1 challenge.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos