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Two decades of molecular surveillance in Senegal reveal changes in known drug resistance mutations associated with historical drug use and seasonal malaria chemoprevention.
Ndiaye, Yaye Die; Wong, Wesley; Thwing, Julie; Schaffner, Stephen S; Tine, Abdoulaye; Diallo, Mamadou Alpha; Deme, Awa; Sy, Mouhammad; Bei, Amy K; Thiaw, Alphonse B; Daniels, Rachel; Ndiaye, Tolla; Gaye, Amy; Ndiaye, Ibrahima Mbaye; Toure, Mariama; Gadiaga, Nogaye; Sene, Aita; Sow, Djiby; Garba, Mamane N; Yade, Mamadou Samba; Dieye, Baba; Diongue, Khadim; Zoumarou, Daba; Ndiaye, Aliou; Gomis, Jules; Fall, Fatou Ba; Ndiop, Medoune; Diallo, Ibrahima; Sene, Doudou; Macinnis, Bronwyn; Seck, Mame Cheikh; Ndiaye, Mouhamadou; Badiane, Aida S; Hartl, Daniel L; Volkman, Sarah K; Wirth, Dyann F; Ndiaye, Daouda.
Afiliación
  • Ndiaye YD; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Wong W; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, 02115, USA.
  • Thwing J; Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA ,30329, USA.
  • Schaffner SS; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
  • Tine A; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Diallo MA; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Deme A; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Sy M; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Bei AK; Yale School of Public Health, 60 College St, New Haven, CT 06510.
  • Thiaw AB; Department of biochemistry and Functional Genomics, Sherbrooke University, 2500 Bd de l'Universite, Sherbrooke, QC J1K 2R1, Canada.
  • Daniels R; RNA Therapeutics Institute, UMass Chan Medical School, 368 Plantation Street, Worcester MA 01605.
  • Ndiaye T; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Gaye A; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Ndiaye IM; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Toure M; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Gadiaga N; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Sene A; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Sow D; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Garba MN; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Yade MS; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Dieye B; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Diongue K; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Zoumarou D; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Ndiaye A; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Gomis J; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Fall FB; Yale School of Public Health, 60 College St, New Haven, CT 06510.
  • Ndiop M; National Malaria Control Program (NMCP), Rue FN 20, Dakar 25270, Senegal.
  • Diallo I; National Malaria Control Program (NMCP), Rue FN 20, Dakar 25270, Senegal.
  • Sene D; National Malaria Control Program (NMCP), Rue FN 20, Dakar 25270, Senegal.
  • Macinnis B; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
  • Seck MC; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Ndiaye M; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Badiane AS; International Research Training Center on Genomics and Health Surveillance (CIGASS), Cheikh Anta Diop University, Dakar, 16477, Senegal.
  • Hartl DL; Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA, 02138 USA.
  • Volkman SK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, 02115, USA.
  • Wirth DF; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
  • Ndiaye D; Simmons University, 300 The Fenway, Boston, MA, 02115, USA.
medRxiv ; 2023 Apr 26.
Article en En | MEDLINE | ID: mdl-37163114
ABSTRACT
Drug resistance in Plasmodium falciparum is a major threat to malaria control efforts. We analyzed data from two decades (2000-2020) of continuous molecular surveillance of P. falciparum parasite strains in Senegal to determine how historical changes in drug administration policy may have affected parasite evolution. We profiled several known drug resistance markers and their surrounding haplotypes using a combination of single nucleotide polymorphism (SNP) molecular surveillance and whole-genome sequence (WGS) based population genomics. We observed rapid changes in drug resistance markers associated with the withdrawal of chloroquine and introduction of sulfadoxine-pyrimethamine in 2003. We also observed a rapid increase in Pfcrt K76T and decline in Pfdhps A437G starting in 2014, which we hypothesize may reflect changes in resistance or fitness caused by seasonal malaria chemoprevention (SMC). Parasite populations evolve rapidly in response to drug use, and SMC preventive efficacy should be closely monitored.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND Problema de salud: 2_enfermedades_transmissibles / 3_malaria / 3_neglected_diseases Tipo de estudio: Risk_factors_studies / Screening_studies Idioma: En Revista: MedRxiv Año: 2023 Tipo del documento: Article País de afiliación: Senegal
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND Problema de salud: 2_enfermedades_transmissibles / 3_malaria / 3_neglected_diseases Tipo de estudio: Risk_factors_studies / Screening_studies Idioma: En Revista: MedRxiv Año: 2023 Tipo del documento: Article País de afiliación: Senegal