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Design, synthesis, evaluation and optimization of potent IRAK4 inhibitors alleviating production of inflammatory cytokines in LPS-induced SIRS model.
Hao, Yongjin; Wang, Jin; Ma, Jiawan; Yu, Xiaoliang; Li, Zhanhui; Wu, Shuwei; Tian, Sheng; Ma, Haikuo; He, Sudan; Zhang, Xiaohu.
Afiliación
  • Hao Y; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
  • Wang J; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
  • Ma J; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
  • Yu X; CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medial College, Beijing, 100005, P. R. China; Suzhou Institute of Systems Medicine, Suzhou, 215123 Jiangsu, P. R. China.
  • Li Z; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
  • Wu S; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, P. R. China. Electronic address: swwu@suda.edu.cn.
  • Tian S; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
  • Ma H; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, P. R. China.
  • He S; CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medial College, Beijing, 100005, P. R. China; Suzhou Institute of Systems Medicine, Suzhou, 215123 Jiangsu, P. R. China; State Key Laboratory of Medical
  • Zhang X; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, P. R. China. Electronic address: xiaohuzhang@suda.edu.cn.
Bioorg Chem ; 137: 106584, 2023 08.
Article en En | MEDLINE | ID: mdl-37163814
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Quinasas Asociadas a Receptores de Interleucina-1 Límite: Animals Idioma: En Revista: Bioorg Chem Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Quinasas Asociadas a Receptores de Interleucina-1 Límite: Animals Idioma: En Revista: Bioorg Chem Año: 2023 Tipo del documento: Article